Ostrix




Mechanism of Action
Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption.

Calcium carbonate- Dietary calcium supplement.Generally prescribed for calcium deficiency state which may occur in diseases such as decreased levels of parathyroid hormone (acute and chronic), postmenopausal osteoporosis, rickets and osteomalacia (softening of the bones).

Zinc is an essential nutritional requirement. It facilitates wound healing, helps maintain normal growth rates, normal skin hydration, and the senses of taste and smell.

Indication
Pre and post menopausal osteoporosis
Parathyroidectomy
Old age osteoporosis
Fractures
Management of hypocalcaemia


Contraindications
Hypercalcaemia; evidence of vitamin D toxicity. Pregnancy (dose exceeding RDA). Lactation. 

Special Precautions
Idiopathic hypercalcaemia. Pediatric doses must be individualised and monitored under close medical supervision. Coronary disease, renal function impairment and arteriosclerosis, especially in the elderly. Hypoparathyroidism. 

Adverse Drug Reactions
Weakness; headache; somnolence; nausea; vomiting; dry mouth; constipation; muscle pain; bone pain; metallic taste; polyuria; polydipsia; anorexia; irritability; weight loss; nocturia; mild acidosis; reversible azotemia; generalized vascular calcification; nephrocalcinosis; conjunctivitis (calcific); pancreatitis; photophobia; rhinorrhoea; pruritus; hyperthermia; decreased libido; elevated BUN; albuminuria; hypercholesterolaemia; elevated AST and ALT; ectopic calcification; hypertension; cardiac arrhythmias. 

Storage
Oral: Store at 15-30°C.




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