STUPAN-D




Mechanism of Action
Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.


Domperidone-Antidopaminergic agent, used in treating nausea, vomiting, gastrointestinal problems and Parkinson’s disease.
Indication
Acidity with nausea
GERD
Heartburn
Peptic ulcer
Dyspepsia
NSAID induced gastritis


Contraindications
Pantoprazole: Hepatic impairment; hypersensitivity. Domperidone: History of hypersensitivity to dimenhydrinate or related compounds; GI haemorrhage, obstruction and perforation, or after surgery, pregnancy. 

Special Precautions
Lactation. Pantoprazole: Not recommended in child <12 yrs. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma. 

Adverse Drug Reactions
Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance. 

Storage
Oral: Store at 25°C.




HyperLink

We also deals in :
Fersul  | STUPAN-D  | Ostrix Forte  | Ricos  | HEPATOX  | METRICH  | LYRIMAX  | Pepiflam Tab  | PEPIFLAM GEL  | JOINSERA FORTE  | Ostrix  | REVISHER  | ADD – ON D3  |

Product/Service Id: 1003317318
Edit  | Report Abuse